ISSN 0975-3583
 

Journal of Cardiovascular Disease Research



    Comparison of Lipid profile, oxidative stress and thyroid hormones levels in infertile women


    Dr Dharmveer Sharma, Dr Kshatrapal Prajapati, Dr Vijay Prasad Sangishetti
    JCDR. 2023: 1447-1452

    Abstract

    Infertility is a major problem worldwide today. It is a global problem affecting about 15% of all couples and about 33% of infertility cases are mainly attributed to women. Several multifactorial causes of female infertility, such as thyroid and sex hormone hormonal imbalances. In recent years, thyroid hormone deficiency and increased oxidative stress have been studied as one of the predisposing factors considered to be very important in the knowledge of causes and diagnosis as well as treatment. AIM: The aim and objective of this study was to compare the lipid profile, oxidative stress and thyroid hormones levels in infertile women with healthy volunteers. Method: A total of 200 subjects were included in this study. Of these, 100 were healthy subjects and 100 cases were infertile women. They were analyzed by measuring of several physiological and biochemical parameters such as age, body mass index, blood parameters such as lipid profile (total cholesterol, triglycerides, low-density lipoprotein, very low-density lipoprotein, high-density lipoprotein), oxidative biomarkers (MDA, catalase, glutathione peroxidase), thyroid hormone levels (T3, T4, TSH), and Prolactin. Result: This study showed that T3, T4 are usually greatly decreased while TSH levels increased in the infertile women group compared to the control group. The results of the present study also showed a significantly increased level of MDA, a significant decrease in the activity of catalase (CAT) and glutathione peroxidase (GPx) in the group of infertile women compared to the control group. Serum total cholesterol, triglycerides, VLDL and LDL levels were greatly increased, while HDL levels were significantly lower in the infertile women group. Conclusion: Thyroid hormone imbalances and increased oxidative stress have been strongly associated with causative and predisposing factors in female infertility

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    Volume & Issue

    Volume 14 Issue 4

    Keywords