Abstract

Liver cirrhosis and its complications are a leading cause of mortality and morbidity in most of the population. Individuals with Cirrhosis demonstrate 90% greater risk of hospitalization, prognostic criteria like the Child Pugh scoring system do not give us an idea of the probability of complications in a patient presenting with cirrhosis of the liver. So use of biomarker such as prolactin, indicate the severity of disease and its complication and serves as a tool for early intervention. The aim is to Compare Serum Prolactin Level with Child Turcottepugh Score for Prognosis in Chronic Liver Disease and establish that serum prolactin is an early marker for complication of cirrhosis if liver. Material and Methods: This was a Descriptive Observational study from July 2021 to August 2022 on 100 patients were admitted in TMMC&RC. Results: In the present study Mean age were 44±12.8 years. The ratio of male CLD patients were higher compared to females. Majority of respondents gives history of alcohol abuse, due to which high level of prolactin is found in them. Almost everyone shows clinical examination like clubbing, edema, pallor and cyanosis. Variables were in a normal range and significance association was found between patients of liver cirrhosis and the different parameters. When CPS test was done taking Age as variant the result came out to be not significant. Majority of patients lies in class B. While when done using occupation as variable, the value came out to be significant. Using ANOVA test, we found that in the Comparison Mean among CPS Class-A, B and C, Total Bilirubin, SGOT, Albumin were found to have significant (P<0.05) at 95% CI. Patients with cirrhosis and elevated prolactin levels have a poor prognosis. Class-A (Pughscores) have lower prolactin levels than patients with class-C (Pugh scores). Conclusion: Increased level of prolactin is seen in patients of liver cirrhosis and CPS is a prognostic factor in determining and classifying the patients into groups. Thus, prolactin levels not only aid in assessing disease severity, but also in predicting complications at an earlier stage of the disease process. Strong relationship have been discovered between the Child-Pugh score and serum PRL So High PRL level could therefore prove useful as a negative prognostic marker of liver cirrhosis

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