Abstract

CAD is the most common heart disease. It can describe asymptomatic atherosclerosis, stable angina, and acute coronary syndrome (unstable angina, NSTEMI, STEMI). Multifactorial CAD. Modifiable and non-modifiable etiologic factors exist. Gender, age, family history, and genetics are unchangeable. Smoking, obesity, cholesterol levels, and psychosocial factors are modifiable. Methods: Institutional Ethics Committee approved the prospective observational case-control study (Regd. No. ECR/84/Inst/OR/2013/RR-20). The Department of Cardiology at S.C.B Medical College and Hospital, Cuttack, comprised 80 CAD outpatients or inpatients between 2020 and 2022. Controls were age- and sex-matched. Patients with acute or chronic kidney illness, traumatic heart disease, head injury, morbidity, or refusal were eliminated. Results: FBS, cholesterol, HDL, LDL, total and direct bilirubin, SGOT, SGPT, and alkaline phosphatase differed between groups (P<0.05). 56.25 percent had severe CAD and 30 percent mild. Cases have greater copeptin than controls (P<0.0001). ROC curve analysis found a cut-off value of 0.98 and sensitivity and specificity of 83.8% and 76.2%. Conclusion: In contrast to healthy controls, CAD patients had greater copeptin levels, according to our study. In these cases, copeptin levels can be employed as a biomarker.

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