Abstract

To correlate C - reactive protein (CRP) with glycosylated haemoglobin (HbA1c) in patients with poorly controlled Type 2 diabetes mellitus; To determine if better control of HbA1c reduces CRP levels. Methods: A hospital based longitudinal study, was done in cohort of outpatients and inpatients diagnosed with Type2 DM attending to Department of General Medicine of MNR Medical College and Research Hospital from January 2021 to July 2022. Results: CRP is well correlated with HbA1c and the elevation in HbA1c levels are significantly correlated with elevation in CRP (P<0.05). Better glycaemic control leading to the reduction in HbA1c also resulted in decrease in CRP levels (P=0.000). CRP also showed significant positive correlation with other atherosclerotic risk factors-like age (P<0.05), duration of type 2 DM (P<0.05) total cholesterol (P<0.05), triglycerides (P<0.05) and also creatinine (P<0.05), which are seen in Diabetic patients. It also showed a negative correlation with HDL-C. CRP level was not significantly correlated with BMI (P= 0.88). Conclusion: This study therefore, reveals that CRP is an additional marker of better glycaemic control and also correlates with the dyslipidaemic profile, seen in T2DM

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