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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Correlation Between HMGB1 and TLR4 Expression in Sinonasal Mucosa in Patients With Chronic Rhinosinusitis


    Dr. Aprajita Pandey, Dr. Williams C.S., Dr. Vikram Singh Rathore, Dr. Ravi Prakash Pandey
    JCDR. 2023: 1717-1727

    Abstract

    Objectives: Chronic rhinosinusitis (CRS) is one of the most common inflammations in the upper airway. Despite the wide prevalence of CRS, the pathogenesis of this disease is poorly understood. Several components of the innate immune system may play a significant role in CRS, including Toll-like receptor 4 (TLR4), TLR9, and high-mobility group box 1 protein (HMGB1). This study was conducted to determine the expression of TLR4, TLR9, HMGB1, and pNFκ-B p65 in paraffin-embedded blocks of patients with CRS with nasal polyps compared with those of the control group.

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    Volume 14 Issue 7

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