Abstract

Osteoarthritis is the most common form of arthritis over all. Serum uric acid (SUA) and serum calcium level are an important biomarker for metabolic diseases and it is related to many forms of arthritis including osteoarthritis (OA). Objectives: The purpose of the study was to explore the association of serum uric acid and serum calcium levels with clinical and radiological severity of knee osteoarthritis. Methods: Patients diagnosed with knee OA attending OPD of orthopaedics department during the study period were enrolled in this study. Basic socio-demographics data and BMI (kg/m2) were recorded. In serological testing quantitative fasting serum uric acid, serum calcium, C-reactive protein and Rheumatoid factor were performed. Results: Majority of them (69.7%) were male, 30.3% were 61-70 year of age, 41.2% belong to lower socio-economic class and 42.4% had normal BMI. Serum uric acid level was significantly associated with the grading of the knee OA. Severity of knee OA increases with the uric acid level. Also, we found a positive association of increasing serum uric acid with progression of the knee joint osteoarthritis (highest tertile in comparison to lowest tertile of serum uric acid odds ratio-2.07. Conclusion: Serum uric acid and serum calcium significantly associated with the progression of knee OA, both are inversely associated with the knee OA.

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