Abstract

Cardiovascular disease (CVD) remains the major cause of death in patients with chronic kidney disease (CKD). Anemia is major independent risk factor for development of left ventricular hypertrophy in chronic kidney disease patients. Objectives of current study were to demonstrate the correlation of anemia with left ventricular hypertrophy in a cohort of CKD patients in a tertiary care centre. Material and Methods: This is observational cross-sectional study conducted over 150 patients of either sex, admitted over a period of one year. The patients were assessed based on clinical history and a number of laboratory parameters including blood urea, serum creatinine, calcium, inorganic phosphorus, serum electrolytes, iPTH level, Hb, Hct, glomerular filtration rate and left ventricular mass index. Left ventricular mass index was calculated by using the ratio of left ventricle mass to body surface area. Results: There is strong correlation between Anemia and left ventricular mass index in both male and female patients. There is linear inverse relationship between left ventricular mass index and Hb (g/dl) i.e., with decrease in Hb value, left ventricular mass index is increasing in male study population. There is linear inverse relationship between left ventricular mass index and Hb (g/dl) i.e.; with decrease in Hb value, left ventricular mass index is increasing in female study population as well. Conclusion: Severity of anemia significantly influences the left ventricular wall thickness in chronic kidney disease patients. These predictors of left ventricle mass could be easily measured and are highly sensitive and specific for the same.

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