Abstract

Dyslipidemia is the main risk factor for Acute Coronary Syndrome (ACS). Atherogenic Index of Plasma (AIP) calculated as logarithm triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) is a reflection of plasma atherogenicity. The aim of this study was to find out the correlation of Atherogenic Index of Plasma with coronary artery disease severity in Non ST segment Elevation Acute Coronary Syndrome(NSTE-ACS). Methods: This crosssectional analytical study was conducted in the department of cardiology, National Heart Foundation Hospital and Research Institute from October, 2019 to August, 2020. Total 120 patients of NSTE-ACS who underwent coronary angiography included after considering inclusion and exclusion criteria, study population was divided into three groups according to AIP; Group I: AIP≤ 0.19 (n=41), Group II: AIP>0.19-0.32 (n=41), Group III: AIP>0.32 (n=38). Baseline characteristics, biochemical variables and coronary disease severity by Gensini score were then compared between the three groups. Results: Participants had a mean age of 56.05± 9.81 years with 81.7% men. AIP was significantly increased with increased Gensini score. There was positive correlation (r= 0.819) observed between AIP and Gensini score, which was statistically significant (p<0.05). Logistic regression analysis showed that AIP was independently associated with severity of coronary artery disease assessed by Gensini score (OR=26.662, p<0.001). Conclusion: Atherogenic Index of Plasma was an independent predictor of coronary artery disease severity in patients with Non ST segment Elevation Acute Coronary Syndrome

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