Abstract

miRNAs are a class of small non-coding, naturally occurring RNA molecule 19-25 nucleotides in length They were first discovered in 1993 by Ambrose et al. when they discovered a small RNA which exerted regulatory functions on a specific mRNA resulting in suppression of its action. This small RNA was subsequently discovered to be a member of an abundant family of tiny regulatory RNAs called miRNAs. Blood samples were collected from 30 colorectal cancer patients admitted at department of surgical gastroenterology. One sample from each collected during preoperative period another sample on post-operative day 7.All the blood samples were collected in EDTA coated blood collection tubes. Plasma Expression values of miRNA-1290 between stage 1 & 2 vs 3&4 among pre-operative blood samples of patients showed no statistically significant relation in our Indian patients. This suggests that in our Indian patient’s plasma miRNA-1290 levels will not correlate with stage of disease.

Description