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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Correlation of triglyceride glucose index as a marker of insulin resistance and heart failure with preserved ejection fraction in obese patients


    Doaa Salah Elgendy, Mie Mohammed Abdalraouf
    JCDR. 2021: 808-816

    Abstract

    Overweight people are more likely to have insulin resistance, which raises their risk of diabetes and cardiovascular diseases. Recently, it has been thought that the triglyceride glucose index (TyG) provides a straightforward substitute for the usual widely utilized measures of insulin resistance. Independent of other known risk factors, such as diabetes and hypertension, obesity is a recognised risk factor for preserved ejection fraction heart failure (HFpEF). TyG index has been linked to the development of cardiovascular disease and hypertension in the prvious studies. The association between the TyG index and the development of heart failure with preserved ejection fraction (HFpEF) in obese individuals has not yet been thoroughly researched. Objectives: To assess the relation between the triglyceride glucose index (TyG) and the incidence of heart failure with preserved ejection fraction (HFpEF) among obese population. Methods: 200 obese individuals were included in this cross-sectional research and divided into two groups: 100 obese individuals without HFpEF and 100 heart failure patients with preserved ejection fraction were admitted to the cardiology department at Menofia University Hospital. Data about patients' demographics, medical histories, current medications, and physical exams were obtained. Results: In comparison with non-HFpEF patients, HFpEF patients had higher fasting blood glucose, fasting insulin, triglycerides, TyG index, left atrial diameter (LAD), left ventricular mass index (LVMI), the ratio of the peak E of the mitral orifice to the peak E of the early diastolic mitral annulus (E/e′), and SBP. Furthermore, there was a positive correlation between the TyG index and NT-proBNP, left atrial diltation(LAD), left ventricular mass index (LVMI), average e′ and E/e′. Conclusion: a higher triglyceride glucose index was found in HFpEF patients which is closely associated to the cardiac diastolic function, both of which have a substantial correlation with the development of HFpEF in obese patients.

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    Volume 12 Issue 1

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