Journal of Cardiovascular Disease Research
Design and Development of Lipid Polymer Hybrid Nanoparticles for Combinatorial Drug Delivery
Mrs Disha Chouhan, Dr Rajesh Mujariya
JCDR. 2023: 639-651
Abstract
In Cancer Therapy there are many problems like multi drugs therapy, short circulation half-life and nonspecific systemic distribution. Important Process to deal with these concerns is to style a drug delivery vehicle that has versatile functionality, good serum stability, circulates within the body long enough to succeed in the targeting tissues and is biocompatible. These features are overcome by formulating the lipid-polymer hybrid nanoparticles. The surface characteristics of these nanoparticles such as charge, lipid density and targeting ligand can be modified to allow for specific cellular uptake, controlled vincristine sulfate and a lomustine releases kinetics, and enhanced pharmacokinetics
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