ISSN 0975-3583
 

Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Development and evaluation of a mucoadhesive microsphere solid dispersion containing cefpodoxime


    M. Deepa , Dr. Lalit Mohan Trivedi , Arindam Kolay , Ashish Kumar Yadav , Nilam Pramod Nile , Ashish Kumar Tiwari , Bhupinder Bhyan , Archita Saxena
    JCDR. 2023: 106-129

    Abstract

    Poorly water-soluble drug Cefpodoxime Proxetil is produced using solid dispersion, which enhances solubility and dissolution. The major goal of this study was to use the solvent evaporation technique to generate a solid dispersion of Cefpodoxime Proxetil in order to increase its solubility and speed of dissolution. The solid dispersions of Cefpodoxime Proxetil were made using water-soluble carriers such as Mannitol, Cyclodextrin, PEG-4000, and PEG6000. F10 (1;1) has the best solid dispersion release profile with -cyclodextrin after examination. These microspheres have a 10% CAP enteric coating. The ideal MS2 formulation was chosen after thoroughly evaluating the aspects of the medication release. The solid dispersion, physical mixture dissolving rate, and characteristics of the drug were all discovered to be greater than those of the intact drug. No chemical incompatibility between the carriers and the medication was found in the FT-IR spectra

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    Volume 14 Issue 7

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