Abstract

This study's goal was to develop a gastroretentive system for metformin hydrochloride. The development and in vitro testing of gastro-retentive floating tablets of metformin are described in the current study. In order to create the formulations, cellulose derivatives like HPMC K4M and HPMC K15M were mixed in various ratios with gas-producing substances and other excipients. By using the direct compression method, floating tablets were created. Citric acid and sodium bicarbonate were utilised as a gas-generating agent. The formulations were evaluated in vitro using a variety of criteria, including hardness, friability, consistent drug content, in vitro floating experiments, in vitro dissolving studies, All of the formulations had nice visual appeal and better physical and mechanical characteristics. The formulation was tested for stability and IR spectroscopy, and it was discovered that it produced the greatest results for drug release and in vitro buoyancy time. The findings show that the formulation was stable and that the medication and polymer did not interact chemically

Description

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