Abstract

Allicin is chemically known as 3-prop-2-enylsulfinylsulfanylprop-1-ene. It is a volatile compound and poorly soluble in water. With molecular weight is 162.3 g/mol, it is also known as Diallyldisulfi-S-oxide, S-allyl-prop-2-ene-1-sulfinothionate and Diallyl thiosulfinate. The primary mode of topical delivery of drugs include ointments, creams, gels, solutions, lotions, foams, shampoos and lacquers, with each mode having their own uses and limitations. To overcome these limitations, there is need for novel approaches for the topical delivery of drugs. Emerging techniques, such as, transdermal patches, microneedles, liposomes, aerosol foams and nanoformulations provides better release profile, stability and bioavailability of drugs. In the present paper Allicin loaded niosomes gel (AN8) were formulated by using thin film hydration technique and plain gel containing allicin was prepared and both were further evaluated.

Description