Abstract

Fine-needle aspiration cytology (FNAC) is the invasive test to determine whether a nodule is malignant or may require surgery to reach a definitive diagnosis. a reliable, noninvasive method to identify which nodules warrant FNAC on the basis of a reasonable likelihood of biologically significant malignancy would be highly desirable. Hence, We compared the Thyroid Imaging Reporting and Data System (TI-RADS) of classifying thyroid nodules on ultrasound with the findings on fine-needle aspiration cytology (FNAC) reported using the Bethesda System. Material and methods: After obtaining ethical committee clearance a prospective study was done in patients with thyroid nodules attending tertiary care hospital during April 2022 to December 2022. After obtaining informed consent from patients, 100 patients were enrolled in the study by purposive sampling method. Patients who were willing for Ultrasound and FNAC underwent bedside imaging of thyroid nodule and ultrasound guided FNAC performed by single radiologist and pathologist. Sensitivity, specificity, disease prevalence, positive and negative predictive value as well as accuracy are expressed were calculated. Results: Mean ± SD of age was 34±12.3. Females were 74%. Based on Bethesda classification on FNAC, 23 patients have malignant lesions (which is Bethesda V and VI) and 77 patients have benign lesions (which is Bethesda < V grade). Sensitivity and specificity of ultrasound over FNAC of thyroid nodule, at 95% CI was 84.21% (60.42% to 96.62%) and 92.5% (84.39% to 97.20%) with accuracy of 90.91% at 95% CI (83.44% to 95.76%). Conclusions: In this study, a significant association was noted between the Ultrasound (TI-RADS) and FNAC (Bethesda scores) (X2- 41.74, p ≤ 0.001). Sensitivity and specificity of ultrasound over FNAC of thyroid nodule, at 95% CI was 84.21% (60.42% to 96.62%) and 92.5% (84.39% to 97.20%).

Description