Abstract

Dengue is a highly infectious endemic disease of tropical countries caused by any of the five dengue virus serotypes: DENVs 1–4, transmitted within humans by the female Aedes mosquito. Dengue infection, ranges from mild asymptomatic dengue fever (DF) to fatal dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) which may turn fatal. Aims and objectives: Secondary dengue infections are more severe than primary infection, hence, distinction between primary and secondary dengue is essential. Demonstration of anti DV IgG in patients’ serum is a way to detect secondary dengue. The present study we explored the association of anti DV IgG positivity and dengue severity. Materials and methods: This study was conducted in Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, India. It was a prospective observational study done from July to December 2015 when the maximum numbers of dengue cases are recorded. Of the 2898 patients recruited Results: Of the 2898 suspected dengue samples tested, 414 were positive for one or more of the three markers (NS1, IgM & IgG). 248 (59.9%) cases were anti DV IgM positive, 143 (34.5%) were Dengue NS-1 positives. Only 23 (5.5%) cases were having detectable anti dengue IgG in their serum (secondary dengue). Of the 414 cases, 391 (94.4%) had primary infection and 23 (5.5%) had secondary infection.

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