Abstract

Cardiovascular effects of thyroid hormones are well known and abnormalities well documented and have attracted a great deal of importance. Present study was aimed to study echocardiographic evaluation of diastolic dysfunction in patients with subclinical hypothyroidism. Material and Methods: Present study was single-center, case control study, conducted patients more than 18 years age, had elevated TSH level higher than the upper limit range 4mU/L but below 10mU/l and normal levels of T3 and T4 without any clinical features of hypothyroidism. Results: In present study, 62 patients were included, 31 cases & 31 controls. There was no statistically significant difference found between cases and controls with respect to age, sex, Triglyceride, LDL, HDL & VLDL. There was a statistically significant difference found between cases and controls with respect to Total Cholesterol, There was a statistically significant difference found between cases (6.70 ± 1.49) and controls (1.70 ± 0.83) with respect to TSH. There was no statistically significant difference found between cases (1.37 ± .37) and controls (1.44 ± 0.34) with respect to free T4. There was a statistically significant difference found between cases and controls with respect to Peak E-early mitral flow rate, Peak A-late mitral flow rate, .E/A ratio, E/E’-early mitral flow velocity/mitral valve tissue velocity. Among those who have sub clinical hypothyroidism 45.2% have abnormal peak E value when compared to 3.2% among controls and this was found to be statistically significant. Similirly 25% of the cases were found to have abnormal peak and 3.2% of the cases were found to be statistically significant. E/A ratio was significant in cases when compared to controls with 29% being abnormal in cases and 3.2% in the controls. DT and E/E' was not significant. Conclusion: Subclinical hypothyroidism is associated with left ventricular diastolic dysfunction.

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