Abstract

Dexmedetomidine has been used in neurosurgery, cardiac surgery, and bariatric surgery, as well as critical care unit as a sedative analgesic. The present study was conducted to assess the effect of Dexmedetomidine when used as an adjunct in off pump Coronary Artery Bypass Grafting on pain profile and hemodynamic changes after extubation. Material & methods: Study was conducted in department of Anesthesia, at a tertiary care centre in Bhopal from January 2021 to August 2022 on 90 patients divided in two groups of 45 patients each. In Group A intravenous dexmedetomidine was given and in Group B intravenous saline was given during induction. Primary outcomes studied were effect on hemodynamic parameters during weaning off mechanical ventilation and extubation. Secondary outcomes were effect on postoperative pain. Statistical analysis was done using version 20. (SPSS Inc., Chicago, IL, USA). p value of less than 0.05 was judged to be statistically significant. Results: Mean heart rate, mean systolic blood pressure, mean diastolic blood pressure at the time of extubation and at 1 hour post extubation was significantly lower in group A as compared to group B.(p<0.01) Mean pain scores immediately post extubation, 1 hr and 4 hr post extubation were significantly lower in group A compared to group B(p<0.01) Conclusion: Dexmedetomidine may be an acceptable anaesthetic for use as an adjunct in off pump coronary artery bypass surgeries due to haemodynamic stability during weaning from ventilation and significant reduction in post operative pain

Description

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