Abstract

Introduction: In the field of anaesthesiology, attenuation of pressor response is one of the keenly researched subjects. As a standard practice we use rigid laryngoscope to view the larynx and adjacent structures for facilitating endotracheal intubation. This causes direct trauma to the oropharynx and larynx and apart from this it also causes stimulation resulting in a rise in heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Tachycardia, hypertension, and dysrhythmias all occur during laryngoscopy and intubations. Aim: This study was done to compare the efficacy of dexmedetomidine 1 μg/kg; and labetalol 0.3 mg/kg in attenuating the cardiovascular responses to Laryngoscopy and Intubation, and to observe for adverse effects if any of these two in the specified dosage. Materials and Methods: This randomized comparative double - blinded study was conducted in Kamineni medical college in the year JAN-DEC 2023. After obtaining ethical committee approval, the study population was chosen all the patients were assessed preoperatively with history, clinical examination, and required investigations, informed written consent was obtained from the patient. The patients were randomly allocated into two groups. Group D (n: 45) received Dexmedetomidine 1 μg/kg in 10ml normal saline IV. Over 10 min, and subsequently 5min after induction of anesthesia was done. Group L (n: 45) received Labetalol 0.3 mg/kg 10 ml normal saline IV. over 10 min, 5 min prior to induction of anesthesia. All patients were pre medicated with Inj. Midazolam 2 mg and Inj. Glycopyrrolate 0.2 mg IV. 45 min before surgery Heart rate, systolic and diastolic blood pressure, and oxygen saturation were recorded as the baseline value.

Description