Abstract

About 30% of cases of infertility are caused by disorders of ovulation. These disorders are often accompanied by irregular periods (oligo menorrhoea) or the absence of periods (amenorrhoea). A veritable avalanche of drugs, methods, and modalities for effective treatment of infertility, particularly anovulation, came at the same time from multiple directions during the 1960s and 1970s. Clomiphene citrate (MRL-41) was first applied in 1961 by Greenblatt et al. This simple, cheap, and relatively safe treatment has enabled thousands of an ovulatory woman to become mothers. A prospective observational study is done on 60 women for a duration of 18 months at the Department of Obstetrics and Gynaecology, Vinayaka Mission Medical College Karaikal, Women less than 35 years of age having primary or secondary infertility, Patient with patent fallopian tubes were included in the study. The results of our study revealed that Sildenafil added to conventional gonadotropin-releasing hormone (GnRH) protocol during ovarian stimulation has, however, been reported to increase endometrial thickness by a non-significant amount.

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