Abstract

To compare effect of sitagliptin alone as monotherapy vs sitagliptin + metformin in combination on pancreatic beta cell function in recently diagnosed type 2 diabetics Material and Methods: This study includes analysis of total 50 patients who were randomly divided in 2 groups of 25 patients each. Group 1 :- Sitagliptin (50mg BD) group, Group 2:- Combination group (Sitagliptin 50 mg + Metformin 1000 mg BD). Lab investigations for a) Fasting and 2 hrs Post prandial glucose b) fasting and post prandial serum insulin levels c) fasting and postprandial c-peptide levels were carried out on blood samples obtained from the patients. Z test was applied as test of significamnce Results: There was a decrease in FBS (Fasting Blood Sugar) as compared to baseline values.Reduction was also noted in levels of PPBS (2hrs post prandial plasma glucose levels in all patients as compared to baseline values. Fasting and postprandial Serum Insulin levels reduced in both groups compared to baseline values There was a reduction in the mean fasting as well as postprandial serum C-peptide levels in both groups Conclusions: these results suggest that the actions of sitagliptin alone as monotherapy as well as in combination with metformin has positive effect on beta cell function. moreover the effect of combination therapy is still better in this regard as compared to monotherapy

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