Abstract

During laparoscopic surgeries immediately after pneumoperitoneum, hemodynamic alterations, which include decreased cardiac output (25%-35%), elevated mean arterial pressure & Increased systemic / pulmonary vascular resistance are seen. Present study was aimed to evaluate and compare the effect of intravenous clonidine versus dexmedetomidine for maintaining haemodynamic stability in patient undergoing laparoscopic surgery. Material and Methods: Present study was hospital based prospective study, conducted in patients of age group 18 - 60 years, of either sex, with ASA physical status I & II, undergoing laparoscopic surgery under general anaesthesia. On the day of surgery, patients were randomly allocated into two groups as group C (received 2µg/kg of clonidine) & group D (received 1 µg/kg of dexmedetomidine) 10 mins prior induction of GA. Results: On comparison of age, gender, weight and duration of surgery in both the groups, p Values were insignificant (p > 0.05). In our study, post-extubation SBP values increased by 9.8% and 8.4% in Group D and Group C respectively. There was significant difference between the two groups (P < 0.05) at T105, T110, T115, T120 and Extubation respectively. There was significant difference between the two groups (P < 0.05) at T95, T100T105, T110, T115, T120 and Extubation respectively. Group D more effectively controlled the dip than group C. There was significant difference between the MAP of two groups (P < 0.05) at T85, T90, T95T100, T110, T115, T120 and Extubation respectively. Regarding hypotension, bradycardia & tachycardia among both the groups, difference was not statistically significant. Conclusion: Our study has shown that, dexmedetomidine blunts haemodynamic response to laryngoscopy and tracheal intubation as well as it also improves intraoperative haemodynamic stability, causes postoperative sedation and decreases analgesic requirement just as clonidine

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