Abstract

Background: Cholelithiasis, or gallstone disease, is a condition marked by the formation of stones within the gallbladder, leading to significant morbidity. Sickle Cell Disease (SCD), a genetic hematological disorder, is prevalent among tribal populations in Eastern Gujarat, India. Chronic hemolysis and hyperbilirubinemia in SCD patients are known risk factors for cholelithiasis, yet the epidemiology and etiopathogenesis in this specific population remain underexplored. Objectives: This study aims to determine the prevalence and etiopathogenesis of cholelithiasis among SCD patients in the tribal populations of Eastern Gujarat. Understanding these relationships can aid in developing targeted healthcare strategies and improving patient outcomes. Methods: A cross-sectional study was conducted with 200 SCD patients from various tribal communities in Eastern Gujarat. Data were collected through structured interviews, clinical examinations, and laboratory tests. Statistical analysis was performed using SPSS software to identify significant factors contributing to the development of cholelithiasis.

Description