Abstract

The transition of females to the postmenopausal state is vulnerable to developing obesity deciding the future development of cardiovascular disease and type II diabetes mellitus in these subjects. Insulin deficiency and resistance affect the lipid metabolism in diabetics. Aim: To assess the correlation of Estradiol and lipid profile to the body mass index in the postmenopausal females having type II diabetes mellitus by evaluating Estradiol and lipid profile based on the BMI. Methods: In 240 postmenopausal females having type 2 diabetes mellitus, venous blood was analyzed for Estradiol, fasting glucose, LDL-C, HDL-C, triglycerides, and total cholesterol. For each subject, weight and height were recorded. BMI was divided into 3 categories as obese (<30), overweight (25-25kg/m2), and normal (<18.5-24.9 kg/m2) categories. Results: Spearman’s correlation was used for assessing the correlation of lipid parameters to Estradiol, it was seen that the significant results were seen with BMI with p=0.02. Estradiol levels were highest in the obese subjects followed by overweight and normal weighted subjects with respective mean values of 1.3, 1.18, and 0.3nmol/l respectively (p=0.04). HDL was higher in normal-weight subjects (42.6±6.37) and reduced significantly to 37.3±4.7 and 31±2.7mg/dl in overweight and obese subjects with p=0.03. Triglyceride levels were significantly higher in overweight subjects followed by obese and normal-weight subjects (p=0.04) Conclusion: The study concludes that postmenopausal obese females having type II diabetes mellitus have high Estradiol concentration and high atherogenic risk profile in them.

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