Abstract

Thyroid dysfunction is the commonest medical challenge among all endocrine disorders globally. It can cause impairment of the lipid profile, which may increase the risk of endothelial dysfunction, hypertension and cardiovascular disease. Aim: To determine the association between thyroid dysfunction and dyslipidemias. Methods: It is a cross-sectional study, in this after estimation of T3, T4 and TSH by Enzyme-linked immunosorbent assay (ELISA) a total of 80 thyroid dysfunction patients and 40 healthy subjects (control group) were taken, among 40 were having hypothyroidism (group-A) and 40 were having hyperthyroidism (group-B). Venous blood samples were collected from all the participants and subjected for the estimation of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) using a fully automatic analyzer. The data were analyzed by using SPSS software version 16.0. Results: When data of hypothyroid (group-A) patients were compared with hyperthyroid patients (group-B) and control group, the mean TC, TG, LDL and VLDL levels were significantly high in group-A(p<0.05), whereas HDL levels were significantly low(p<0.05). Conclusion: Hypothyroidism patients had shown significantly high levels of TC, TG, LDL and VLDL and low HDL levels, which may be the predisposing factor for high risk of endothelial dysfunction, hypertension and cardiovascular disease.

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