Abstract

Introduction; Diabetes mellitus is a metabolic disorder resulting from insufficient insulin production or decreased insulin effectiveness, or both. The development of diabetic complications is often attributed to oxidative stress, which arises from an imbalance between the production and elimination of free radicals. Aim: To assess the extent of oxidative stress in individuals with type-2 diabetes mellitus in comparison to healthy individuals. Materials and methods: A total of 140 participants were enrolled in this study, with 70 participants being healthy individuals (group A) and the remaining 70 participants were diagnosed with type 2 DM (group B). Blood samples were collected from each participant to measure various parameters related to blood glucose, including glycosylated hemoglobin (HbA1c %), fasting blood sugar (FBS mg/dl), postprandial blood sugar (PPBS mg/dl), as well as oxidative stress markers such as malondialdehyde (MDA) and total antioxidant capacity. Results: Upon conducting a comparison between the groups, it was noted that individuals with diabetes mellitus (group B) demonstrated higher levels of HbA1c, FBS, PPBS, and MDA, while the healthy participants (group A) exhibited higher levels of Total Antioxidant Capacity. This disparity was found to be statistically significant (p<0.05).

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