Abstract

To analyse the vitamin D levels in COPD patients and to correlate with disease severity Methodology: A case control study was carried out during the period of January 2018 to June 2019. Chronic obstructive pulmonary disease patients and healthy volunteers with age group of more than 30 to 75 years were selected for the study. The total numbers of samples for the study were 40 cases and 40 control attending the outpatient & inpatient Department of Pulmonary medicine and General medicine, Ayaan Institute of Medical Sciences, Hyderabad, Telangana, India. Results: The study concludes that there is an increase in the incidence of COPD among males (64%). The mean age of the COPD cases and Controls are 55.9 ± 6.90 and 52.74 ± 8.62. 62.5% of the COPD patients are smokers, while 38% had COPD due to various factors like Biomass fuel exposure, Occupational exposure. Most of the COPD patients were within the normal BMI (75%). 15% of them are underweight and 10% had high BMI. The mean Vitamin D level among COPD patients and Healthy volunteers in the present study are 30.11 ± 11.58 and 50.05 ± 2.99 respectively. Vitamin D deficiency is present in 40% of COPD patients and 12% of controls. Vitamin D levels correlate inversely with the increase in severity of COPD. In the present study the mean Vitamin D levels among COPD patients with less than 2 exacerbations/year and more than ≥2 exacerbations/year are 39.26±6.41 and 31.04±13.11 respectively. Conclusion: Vitamin D levels are reduced with increase in the severity of COPD. There is also reduction in vitamin D level with increased exacerbations of COPD.

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