Abstract

Introduction: Candidiasis is a serious fungal infection mostly caused by Candida albicans in humans. Candida albicans is an opportunistic infection in immunocompromised people that has proved fatal despite antifungal treatment. The rise in antibiotic resistance in C. albicans is concerning, as it is in the human microbiome. Aim and Objective: To detect the antifungal sensitivity pattern of Candida albicans isolated from various clinical samples to Fluconazole and Amphotericin B using the Kirby Bauer disc diffusion method and the Broth microdilution method. Materials and Methods: This was a cross sectional study carried out in the Department of Microbiology at a tertiary care centre, Uttar Pradesh for a period of 1 year i.e, February 2023 to February 2024. A total of 100 isolates of Candida species from different clinical specimens like blood, BAL, urine, Pus, Et secreation and vaginal secreation were evaluated for its susceptibility against Fluconazole and Amphotericin B using Kirby Bauer disc diffusion method and Broth micro dilution method according to the CLSI guidelines 2023.

Description