Abstract

Inflammatory conditions are characterized by the production of prostaglandins, which are synthesized by the enzyme cyclooxygenase (COX). COX-2, an inducible isoform, is primarily responsible for prostaglandin production during inflammation. Objectives: This study aimed to assess the anti-inflammatory and analgesic properties of a dexibuprofen, in albino rats. Methods: The anti-inflammatory and analgesic properties of dexibuprofen were assessed using two animal models: the carrageenan-induced paw edema model, which measures paw volume as an indicator of inflammation, and the acetic acid-induced writhing model, which quantifies writhing as a measure of pain response in rats.Results: Treatment with dexibuprofen, , significantly reduced paw volume in the carrageenan-induced paw edema model compared to the control group. The anti-inflammatory effect of dexibuprofen was comparable to that of the standard NSAID. Moreover, dexibuprofen significantly reduced the number of writhes in the acetic acid-induced writhing model, demonstrating an analgesic effect similar to the standard NSAID. Conclusion: Dexibuprofen, exhibited potent anti-inflammatory and analgesic properties in animal models of inflammation and pain. These results suggest that dexibuprofen may hold therapeutic potential for the treatment of inflammatory and painful conditions

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