Abstract

Introduction: Apelin is known to modulate adipogenesis, enhance fatty acid oxidation, and regulate insulin secretion in diabetes mellitus (DM). Furthermore, apelin-activated pathways are implicated in the development of DM-related complications. On the other hand, resistin is believed to function as a hormone with insulin antagonist properties, impacting glucose metabolism significantly.The primary aim of this investigation was to evaluate the levels of serum apelin and resistin among individuals with impaired fasting glucose, juxtaposed against a cohort of healthy controls. Methods: In this study, we recruited a total of 200 participants diagnosed with impaired glucose tolerance (IGT), and 200 healthy controls. Comprehensive assessments encompassed the measurement of serum apelin and resistin levels, alongside evaluations of fasting and postprandial blood glucose, markers indicative of insulin resistance, and lipid profiles. Results: Our analyses uncovered a noteworthy decrease in serum apelin levels within the IGT group when compared to the control group. Conversely, serum resistin levels demonstrated a marked elevation in the IGT cohort compared to their healthy counterparts.

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