Abstract

Inadequate plane of anesthesia while doing laryngoscopy and intubation result in significant hemodynamic response. Fentanyl citrate suppresses upper airway reflexes and is effective in blunting the response while laryngoscopy and intubation. This study was carried out to compare three different doses of fentanyl (2, 3 and 4μg/kg) for attenuation of stress response to laryngoscopy and intubation. Methods Study design: Randomized double-blind study conducted at Krishna Institute of Medical Sciences Ltd. Secunderabad from November 2018 to January 2020.Total sample size was 111. The patients were randomly allocated in a double-blind fashion using computer Generated randomization table and divided in to three groups. Group -A received inj. FENTANYL 2 μg/kg IV, Group - B received inj. FENTANYL3 μg/kg IV, and Group--C received inj. FENTANYL 4 μg/kg IV5 min before induction of anesthesia. Results The difference between the groups was found to be highly significant at the time of intubation (p value < 0.001), 1 minute after intubation (p value <0.001), 3 minutes after Intubation (p value < 0.001), 5 minutes after intubation (p value < 0.001).Attenuation of Heart rate and systolic blood pressure at various time intervals was found to be highly significant with Group C (Fentanyl 4 mcg/kg) when compared to Group A (2 mcg/kg)and Group B(3mcg/kg). Conclusion This study showed that fentanyl 4 μg/kg resulted in better attenuation of stress response when compared to 3μg/kg fentanyl, 2μg/kg fentanyl to laryngoscopy and intubation in laparoscopic surgeries.

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