Abstract

Diuretics are required for various pathological conditions with fluid overload. Our study has evaluated the diuretic activity of hydroalcoholic extract of whole plant Mimosa pudica (HAEWMP) as an alternative/new drug which may induce diuresis. Materials and Methods: HAEWMP was prepared using Soxhlet’s apparatus. Albino rats were divided into 5 groups of 6 rats each. Group-I (Control) received distilled water 25ml/kg orally. Group-II (Standard) received Hydrochlorothiazide 2.5 mg/kg orally, Group-III, IV and V 200 mg/kg, 400 mg/kg and 800 mg/kg. The urine samples were collected for all the groups at 5 and 24 hours and urine volume were measured. The urinary excretion percentage, diuretic activity and electrolytes (Na+, K+) were estimated. Results: HAEWMP exhibited significant dose dependent diuretic activity by increasing urine volume and also by enhancing elimination of Sodium (Na+), Potassium (K+). The diuretic activity of 200mg/kg and 400mg/kg was moderate and that of 800mg/kg was good. Conclusion: HAEWMP possesses significant diuretic activity and has a beneficial role in volume overload condition

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