Abstract

Introduction: Dexmedetomidine can decrease the duration and intensity of postoperative pain due to their anti-nociceptive effects. Dexmedetomidine acts on dorsal root neurons to block the pain pathway. Aim: To compare the analgesic efficacy and duration of postoperative analgesia after intraperitoneal instillation of bupivacaine with dexmedetomidine to bupivacaine alone in laparoscopic cholecystectomy. Materials and Methods: The present study was a randomized controlled study, in which 60 patients of age 18-60 years, belonging to American Society of Anesthesiologists (ASA) grade I or II were randomly selected and divided in two groups. Patients of Group D received dexmedetomidine 1 µg/kg with 0.25% bupivacaine 30 mL, and patients of Group B received 0.25% of plain bupivacaine 30 mL . postoperative pain was assessed using Visual Analog Scale (VAS) score as primary outcome . Time to rescue analgesia (VAS ≥4 or on demand) and patients satisfaction score were the secondary outcomes. All recorded data were analyzed by statistical tests (Analysis of Variance (ANOVA), posthoc Tukey’s HSD (Honest Significant Difference) test and Chi-square test). Results: Time to first rescue analgesia was highest in Group D as compared to Group B .The mean VAS score was 2.57±0.78 and 2.88±0.92 Group D and Group B, respectively (<0.05).Total analgesic requirement ( Paracetamole) in first 24 Hrs postoperatively was lower in Group D (2.17±0.53 gm) as compared to Group B (2.87±0.47 gm ). Highly satisfied patients in group D was 03 none in Group B. There were 18 dissatisfied and highly dissatisfied patients in group B as compared to 07 in Group D. This difference in patients satisfaction score was statistically significant (P= 0.0002) .

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