ISSN 0975-3583
 

Journal of Cardiovascular Disease Research



    Evaluation of HPV in selected cases of premalignant and malignant lesions of cervix by real time PCR


    Dr. Uma K, Dr. Ankita Das, Dr Rashmi SP
    JCDR. 2023: 3605-3610

    Abstract

    The aim of the present study was to evaluate HPV in selected cases of premalignant and malignant lesions of cervix by Real Time PCR. Methods: The present study was a prospective study done over a period of 2 years from Jan 2019 to Jan 2021 in the Department of Pathology, Akash Institute of Medical Sciences and Research Centre, Devanahalli, Bangalore. The study material comprised of 75 Cervix punch biopsies received from the Department of OBG, Akash Hospital, Devanahalli. Results: Analysis of the background characteristics of women in the study revealed that three fourths of the women in the study were in the age range of 31-50 years and had no education, with only 24.67% having primary education. Most of them were housewives attending only farm, married after 20yrs of age (61.35%). 523 cases, .i.e., 68.69% of patients had 1-2 children and most of them do not give history of any contraceptive use. It was observed that 56% (421) of the cases were reported as Chronic Non-Specific cervicitis followed by a significant number of cases presenting as Carcinoma Cervix (30%). On the whole CIN accounted for 10% and cervical polyps in 4% of cases respectively. Conclusion: A combination of HPV testing and Pap testing is an option for screening women age 30 and older. Regular surveillance can increase the possibility that cancer could be found at an early stage when treatment is most likely to produce a cure. With the advent of molecular techniques, particularly PCR, it is now possible to detect very low quantities of HPV and also to subtype the commonly occurring HPV in cervical scrape smears.

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    Volume & Issue

    Volume 14 Issue 1

    Keywords