Abstract

Introduction: Tobacco is very harmful to our body. It contains five thousand of injurious chemicals injurious for our body and heart and cause various diseases like lung, oral cancers and obstructive pulmonary diseases. It is a serious threat for health. Smoking causes deaths. India ranks second as a cause of death in the world. Objectives of the study: to determine the levels of MDA as marker of oxidative stress, total antioxidant capacity and oxidized LDL in adult smokers. Methodology: Fasting Venous blood (5 ml) was collected under taking aseptic precautions and the serum was separated used for the estimation of Oxidised LDL (Ox-LDL), total antioxidant capacity (TAOC) and malondialdehyde (MDA) . Results: In the present study, Ox-LDL and MDA were significantly increased & TAOC (Total antioxidant capacity) was significantly decreased (p < 0.005) in smokers compared to non-smokers. Conclusion: Our study provides the evidence that total antioxidant capacity is decreased in smokers as compared to healthy controls. Levels of MDA and Ox-LDL is increased in smokers as compared to healthy controls.

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