Abstract

Gall bladder cancer (GBC) is one of the commonest malignancies of hepatobiliary tract which progresses silently and has a poorer outcome. Thus, we evaluated the time of presentation and compounding risk factors in GBC. Materials and Methods: This was a single centre, prospective, observational study performed in the Department of General Surgery over a period of 18 months. A total of 100 patients diagnosed with GBC, underwent ultrasonography (USG), Computed Tomography (CT), Magnetic Resonance Cholangiopancreatography (MRCP), biopsy, or fine needle aspiration cytology (FNAC). Results: The patients were predominantly females (57%), and the mean age of the patients was 55.57 ± 9.3217 years. Most common presenting symptoms were nausea/vomiting (72%) and abdominal pain (63%) with mean duration of diseases as 12.39 ± 8.77 months. GB fossa mass with extension in liver metastasis with multiple calculi within GB (22%), and GB wall thickening suspicious of malignancy (20%) were the commonest findings on USG and CT, respectively. The predominant finding on MRCP was obstructive jaundice with dilated intrahepatic biliary radicals, common bile duct, main pancreatic duct due to common bile duct calculi (25%). Moderately differentiated adenocarcinoma was the most frequent finding on biopsy (67%), and FNAC (50%). Due to inoperable nature of the disease, patients mainly received chemo-radiation (70%), while 10% underwent exploratory laparotomy. Conclusion: GBC is rare disease with poor prognosis with most of the cases presenting in late

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