Abstract

The aim of the present study was to evaluate platelet indices and hsCRP to predict microvascular complications among diabetics Methods: A total of 200 participants were enrolled, which included 100 cases and 100 controls. Among both the cases and controls, 60 were male patients and 40 were female patients. All patients with diabetic range sugar were included as cases. The controls were all non-diabetics. Diabetics were further divided into two groups-Group A with HbA1C < 6.5% and Group B with HbA1C values > 6.5%. Platelet indices (MPV, PDW and PLCR) and hsCRP were measured for both cases and controls. Results: The age group and platelet counts in both groups were comparable. There were a higher percentage of individuals with abdominal obesity among diabetics than among non-diabetics. The platelet indices- MPV (11.45 fL vs. 8.56 fL, p < 0.0001), PDW (15.68% vs. 11.43%, p <0.0001), PLCR (46.3% vs. 32.4%, p <0.0001) were higher among cases than controls respectively. Platelet indices- MPV (12.3 fL vs. 10.68 fL, p < 0.0001), PDW (16.7% vs. 10.8%, p <0.0001), PLCR (47.4% vs. 45.6%, p <0.0001) were higher among diabetics with complications than diabetics without complications respectively. Furthermore, hsCRP were significantly higher among diabetics than among non-diabetics (4.33mg/L vs. 2.8mg/L, p<0.001). Conclusion: Our study showed a positive correlation between Diabetes mellitus and platelet activation and reactivity as indicated by increased platelet indices. High HbA1C and diabetic complications which indicate poor glycaemic control are associated with higher platelet indices. One of the important outcomes of our study is the positive correlation between high platelet indices and diabetic complications, indicating role of increased platelet reactivity in the microvascular and macrovascular complications of diabetes mellitus. Furthermore our study has found a positive correlation between hsCRP an inflammatory marker and diabetes mellitus.

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