Abstract

Background: Evaluation of adiponectin levels in PCOS women might help to understand the pathogenesis of the syndrome as well as the complications associated with it. These provide clinical implications for therapeutic interventions targeted at adiponectin in order to prevent the complications associated with polycystic ovary syndrome. Materials and Methods: The present study included a total of sixty (60) women with polycystic ovary syndrome and thirty (30) age matched healthy women were recruited as controls. The blood samples were collected from all the subjects and the biochemical, clinical and experimental parameters were analyzed. Results: Fasting blood sugar levels were similar in PCOS women and controls. Among the lipid parameters studied, total cholesterol and triglycerides were significantly higher in PCOS women when compared to controls, whereas HDL cholesterol levels were similar in PCOS women and controls. Fasting insulin levels and HOMA-IR were similar in PCOS women and controls. Serum adiponectin levels were significantly lower in PCOS women compared to controls. Conclusion: Adiponectin levels are decreased in PCOS women. These decreased levels may further result in the complications associated with polycystic ovary syndrome and hence evaluation of adiponectin levels in these women and measures to improve the levels might provide beneficial effects.

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