ISSN 0975-3583

Journal of Cardiovascular Disease Research

    Exploring the Design, Synthesis, and Comprehensive Biological Evaluation of Novel Imidazo[1‐b][1,3,4]thiadiazole Derivatives for Potential Therapeutic Applications

    Prashanti Chitrapu, Habibullah Khaliullah, Dr. Vinay Hiralal Singh, Dr. Gajanan Chandrakant Upadhye, Harit Kumar Rawal, Mr. Ankur Agrawal, Dr Shahulhussain SK
    JCDR. 2024: 924-933


    In order to manufacture imidazo[1‐b][1,3,4]thiadiazole, the beginning components that are used are the 2,4-dinitro benzoic acid and the thiosemicarbazide. The synthesis of the corresponding imidazolthadiazole derivative was brought about as a consequence of their interaction with phenacyl bromides, which are also referred to as p-substituted phenacyl bromides. The structure of these compounds was validated since the spectrum features of the compounds that were discussed before were taken into consideration. A couple of these compounds were shown to have an effect that varied from mild to moderate against the microorganisms Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa, and Escherichia coli. This was identified via the process of discovery.


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    Volume & Issue

    Volume 15 Issue 2


    1,3,4-thiadiazole, thiosemicarbazide, phenacyl bromide, antimicrobial activity