Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood glucose levels. Various factors, including mineral imbalances, have been implicated in the pathogenesis of T2DM. Objectives: to investigate the relationship between serum copper, magnesium, and glycated hemoglobin (HbA1c) levels in individuals with T2DM.Methods: A cross-sectional study was conducted on 150 patients diagnosed with T2DM. Serum copper and magnesium levels were measured using atomic absorption spectrophotometry, while HbA1c levels were determined using high-performance liquid chromatography. Statistical analysis was performed to assess the association between serum copper, magnesium, and HbA1c levels, considering potential confounding variables.Results: The mean serum copper level was found to be significantly higher in individuals with T2DM compared to the control group (p < 0.001). In contrast, the mean serum magnesium level was significantly lower in the T2DM group (p < 0.001). Furthermore, HbA1c levels were significantly elevated in individuals with T2DM (p < 0.001). Pearson's correlation analysis revealed a positive correlation between serum copper and HbA1c levels (r = 0.387, p < 0.001), while serum magnesium showed a negative correlation with HbA1c levels (r = -0.298, p < 0.001). Multiple regression analysis confirmed these associations after adjusting for potential confounders.Conclusion: Our findings suggest that altered serum copper and magnesium levels are associated with glycemic control in individuals with T2DM. Further research is warranted to explore the underlying mechanisms and potential therapeutic implications of these mineral imbalances in T2DM management

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