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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    EXPRESSION OF GALECTIN-3 IN THYROID NEOPLASM


    Dr. Suddha Sattwa Bandyopadhyay, Dr. V.B. Shivkumar, Dr. Manisha Atram, Dr. Pravin Ghongade, Dr. Sudesna Debnath
    JCDR. 2024: 101-110

    Abstract

    BACKGROUND Thyroid cancer is the most common malignant endocrine cancer worldwide. The diagnosis and distinction between benign and malignant thyroid neoplasm, especially in follicular patterned thyroid lesions is still difficult. Of the various immuno histochemical markers, Galectin-3 was most reliable in diagnosis of thyroid carcinoma. AIM To study diagnostic utility of Galectin-3 in thyroid neoplasm. METHODS This was laboratory based diagnostic study, where 92 cases of thyroid neoplasm (48- malignant and 44 benign) were analyzed for Galectin -3 expression. The Galectin- 3 staining was quantitatively evaluated as percentage of positive tumor cells and qualitatively for intensity of staining. When membrane ± cytoplasmic immunoreactivity of Galectin -3 was present in more than 10% of tumor cells was considered as positive staining.

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    Volume 15 Issue 6

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