Journal of Cardiovascular Disease Research
Formulation and Characterization of Toremifene Self-Microemulsifying Drug Delivery System for Enhancement of Oral Bioavailability
Ajit Kumar Varma , Sarvan , Sahil Kumar , Rani Kumari , Ravi Kumar , Rajeev Ranjan , Rajat , Nihar Ranjan Kar , Dr. Mohit Kotnala
JCDR. 2023: 273-299
Abstract
The limited water solubility and dissolution of drugs classified under the Biopharmaceutics Classification System (BCS) class II category provide constraints on their oral bioavailability. In the present study, a self-micro emulsifying drug delivery system (SMEDDS) was employed to enhance the aqueous solubility and oral bioavailability of toremifene, which belongs to the Biopharmaceutics Classification System (BCS) class II category
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