Abstract

The goal of the current study was to provide a unique approach to improve risedronate sodium's bioavailability, since it absorbs poorly and inconsistently. Using the modified quasi-emulsion solvent diffusion technique, nanosponges were statistically developed through a full 32 factorial design with Design of Experiment software, taking into account the concentration of the polymer and stabilizer as independent variables and the particle size and entrapment efficiency as experimental responses. The optimized formulation had a zeta potential of -35.4 mV, a particle size of 155.8±2.17 nm, and an entrapment efficiency of 67.27±1.05%. According to the Higuchi model's diffusion-controlled release mechanism, the in vitro release study's findings demonstrated burst release during the first two hours, followed by gradual and sustained release over the next 24 hours. A research using scanning electron microscopy revealed consistently separated, spherical particles with a porous surface that did not aggregate. Particle size, entrapment efficiency, and in vitro release did not significantly alter, according to the stability research, indicating the stability of the nanosponge formulation. As a result, it seemed that the nanosponges were an appropriate kind of nanocarrier system that could significantly enhance the osteoporotic state.

Description