Abstract

Oral controlled-release drug delivery systems are designed to deliver drugs at a predictable time, thereby increasing efficacy, reducing side effects, and helping to increase drug bioavailability. In addition to various application methods, the safest, easiest and most convenient method is the oral method, as it has many advantages in terms of cost, ease of management and relations with the patient. The disadvantages of prescriptions can be overcome using technology that led to the development of CRDDS. This new technique could help transform pain management with many therapeutic benefits. Four types of EC, EC: HPMC 5, 100 and 4000 cps formulations were developed, optimized and evaluated, respectively.The formulations are available in the right size and have good in vitro compatibility. All formulations have high drug encapsulation efficiency and product yield. The drug-polymer ratio, rotational speed, and emulsifier concentration affect the shape, size, and other parameters during operation. The short half-life allows rapid elimination of NG, thereby facilitating delivery from the gastrointestinal tract.

Description

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