Abstract

This study aims to construct and characterise oral films of furosemide made by solvent casting method based on Lepidium sativum and synthetic disintegrant. The films were made with PEG-400 acting as a plasticizer, Lepidium sativum mucilage acting as a natural disintegrant, and copovidone acting as a synthetic disintegrant. HPMC was used as the film-forming polymer. A loop diuretic called furosemide keeps our bodies from absorbing excessive amounts of salt. It is used to treat excessive blood pressure as well as fluid retention (edoema) in patients with liver illness, congestive heart failure, and kidney disorders such nephrotic syndrome. Its oral bioavailability is 60% and its solubility is low. In order to maximise bioavailability by rapid solubilization, furosemide was developed as a fast-dissolving film.

Description