Abstract

Both in the developed world and in the developing world, coronary artery disease (CAD) is a primary cause of illness and mortality. Aim: intravascular ultrasonography (IVUS) and fractional flow reserve (FFR) were used to evaluate intermediate coronary lesions identified by visual assessment in coronary angiography, and the ideal minimal lumen area (MLA) was determined using IVUS, correlating with functionally relevant FFR. Methodology: This cross sectional, prospective study was carried out on 100 patients had intermediate coronary artery lesion on elective coronary angiography. All patients were subjected to resting standard 12-leads electrocardiogram, laboratory investigation (CBC, renal function test (urea and creatinine) and lipid profile), Echocardiography, coronary angiography, IVUS and FFR. Results: It was clear that with a sensitivity and specificity of 63.41 and 77.97%, a PPV of 66.67 and an NPV of 75.41, and an overall accuracy of 72.0%, MLA values ≤ 3.15 mm2 was shown to be the most concordant with ischemic FFR values. correlation coefficient curve done and showed moderate correlation between IVUS and FFR with p value = 0.010 and r 0.358. Conclusions: IVUS measurements of coronary lesions at the intermediate severity level correlated moderately with FFR measures. MLA > 3.15 mm2 as determined by IVUS had the potential to rule out FFR ≤ 0. 80. In conditions where FFR/adenosine are inadvisable or intolerable, this may be of paramount relevance. The hemodynamics of coronary flow were influenced by a number of factors, including MLA.

Description