Abstract

Introduction: Liver cirrhosis represents the final stage of liver fibrosis, stemming from prolonged injury to the liver. At the microscopic level, it is characterized by the formation of regenerative nodules comprised of hepatocytes, surrounded by fibrotic tissue. This disrupts the normal architecture of the liver, impairing its function. The exchange of blood between the sinusoids and the liver tissue is compromised due to the redirection of portal and arterial blood directly into the hepatic outflow, leading to further dysfunction. Clinically, liver cirrhosis manifests with various complications, including impaired liver function, portal hypertension, and an increased risk of hepatocellular carcinoma. Although a quarter of cirrhotic livers may appear morphologically normal, imaging studies such as computed tomography often reveal widespread atrophy in over a third of cases, along with focal hypertrophy, particularly noticeable in the caudate lobe. This hypertrophy often occurs alongside segmental atrophy of the right lobe. The Caudate lobe to right lobe ratio (C/RL ratio) serves as a crucial morphological measurement to assess the alterations in cirrhotic livers. A globally accepted value for this ratio, typically above 0.65, suggests the presence of liver cirrhosis. Therefore, understanding variations in the C/RL ratio is essential for diagnosing and monitoring the progression of cirrhosis. This study seeks to analyze the morphometric measurements of the right lobe in human cadaveric livers, specifically focusing on the C/RL ratio. By doing so, it aims to establish a baseline dataset against which future studies can be compared.

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