Abstract

Background: Diarrheal illness can be associated with significant morbidity and mortality, especially in very young, elderly population and those with co morbid medical illness. Diarrhea can be classified based on the duration into acute, persistent and chronic. Chronic diarrhea is defined in adults by abnormal stool weight (>200 g/day), consistency (loose or liquid), and/or frequency (>3 times/day) lasting for more than 4 weeks. Aim & Objective:1. Study Histo morphological study of colonoscopic biopsies in patients presenting with chronic diarrhea 2.Study incidence of pathological causes of chronic diarrhea. Methods: Study design: Prospective observational Study. Study setting: Department of Pathology, Dr. D.Y Patil Medical College and Research Institute, Kolhapur .Study duration: From September 2022 to September 2023. Study population: A total of 100 colonoscopic biopsies from the patients who presented with chronic diarrhea attending Department of Pathology, Dr. D.Y Patil Medical College and Research Institute, Kolhapur. Sample size: 100. Results: majority of cases were from 31-50 years age group e.g. 37 followed by 30 cases in 51-70 years age group,23 cases in above 70 years and 10 cases found in 18-30 years age group. most of the cases were Males contributing 67% and 33% were females. all cases presented with Diarrhea and associated with pain in abdomen 40 cases, 17 cases reported weight loss and 10 cases with fatigue. most of cases found with Ulceration 55 followed by Neutrophilic infiltrates 39, Cryptitis 26, Crypt abscess 22, Submucosal edema 18, Architectural distortion 15, Granulomas 12 and 10 cases found with Lymphoplasmacytic infiltration. majority of cases diagnosed with non specific colitis 34 followed by active and chronic colitis 30 cases, tuberculous colitis 11, ulcerative colitis 11,crohns disease 5, neoplasia 4, polyps 2, lymphocytic colitis 2 and 1 cases diagnosed with melanosis coli. Conclusion: Colonoscopic biopsies have increased the role of pathologists in the diagnosis and management of patients with chronic diarrhea so that proper clinicopathological correlation can be made to assess severity and to guide treatment accordingly.

Description