Abstract

In this study, we wanted to do ahistopathological analysis of changes in gastric mucosa in patients who turn positive for H. pylori through rapid urease test. Methods: This was a prospective study conducted among 40 patients who underwent UGIscopy in the Department of General Surgery in PSG Hospitals for a period of two yearsfrom November 2017 to November 2019, after obtaining clearance from the Institutional Ethics Committee, and written informed consent from the study participants. Results: There was no statistical significance between site of occurrence with regard to presence of polymorphs, atrophic changes, presence of H. pylori, and lymphoid hyperplasia. Parietal hyperplasia was present in 22.5% of biopsies from body of stomach, 7.5 % from antral and incisura biopsies. There was a statistical significance between site of occurrence. There was no statistical significance between age, and the site of occurrence of polymorphs, atrophy changes, H. pylori changes, parietal hyperplasia, or lymphoid hyperplasia. Conclusions: H. pylori kit was highly sensitive and gives a rapid report when compared to histopathology and is easy to perform. Antrum is the most common site affected by H. pylori. Atrophic gastritis is seen in 15% of the patients, hence required long term follow-up to detect early malignancies. Young males were mostly affected by H. pylori when compared to elder population.

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