Abstract

The present study was conducted for carrying out histopathological assessment of gallbladder mucosa among gallstone patients. Materials & methods: 100 gallstone patients were enrolled. Gross examination of size of gallstones was done. The gallbladder mucosal tissue was properly sampled and processed by routine histological techniques by hematoxylin and eosin staining of the sections. The various morphological responses were then categorized into four broad categories – cholecystitis, hyperplasia, metaplasia, and carcinoma. Results: Chronic cholecystitis was the diagnosis in 81 percent of the patients while chronic cholecystitis with hyperplasia was the diagnosis in 11 percent of the patients. Chronic cholecystitis with metaplasia was the diagnosis in 5 percent of the patients while papillary carcinoma was the diagnosis in 3 percent of the patients. While assessing the correlation of histopathologic diagnosis with gallstone size, significant results were obtained. Conclusion: As the gallstone size increases, the reaction in the gallbladder mucosa changes from cholecystitis, hyperplasia, and metaplasia to carcinoma. Chronic cholecystitis is the most common histopathological diagnosis and 3 % patients had incidental Gall bladder carcinoma

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